This document outlines broad operational guidelines for the San Francisco Syringe Access and Disposal Program (referred to throughout this document as Syringe Programs or “SP”s). It is intended as a framework for organizations, whether or not they receive funding from the San Francisco Department of Public Health (SFDPH), to develop detailed operational guidelines appropriate to their own settings. These guidelines summarize best practices based on public health strategies. Organizations that are not funded by SFDPH must adhere to these policies and guidelines as a condition of authorization. SFDPH will provide this document to all SPs authorized by the City & County of San Francisco.