Methamphetamines are a major driver in the HIV epidemic. MSM who use meth are two to three times more likely to engage in risk behaviors that could lead to HIV. While medications exist to treat opiate, nicotine, and alcohol dependencies, currently there are no medications approved for methamphetamine addiction. The “BUMP” studies are designed to determine if medications can help individuals who use meth to stop or decrease their meth use and reduce the associated HIV risk behaviors.